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Choosing a sample size that seems feasible in a cer-tain time frame and then specifying the effect size is an inappropriateapproach, because the effect size could be quite different in reality from whatwas expected. Infants acutely increase their end-expi-ratory lung volume (EELV) and maintain it aboveresting lung volume by modulating (abbreviating)their expiratory time (Mortola and Saetta 1987)(Fig. Consistent with the high bind-ing afnity for MDM2 and disruption of the MDM2-p53 complex, spiro-oxindolesinduced accumulation of p53 in p53 wild-type cancer cells, and it showed anti-tumor activity in human tumour xenograft models Consistent with the high bind-ing afnity for MDM2 and disruption of the MDM2-p53 complex, spiro-oxindolesinduced accumulation of p53 in p53 wild-type cancer cells, and it showed anti-tumor activity in human tumour xenograft models.
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